Malaria

For therapeutic products

• Anti-malarial drugs:
  • Drug ingredients: The active ingredient content of the drug should meet the specified standards, and the impurity content should not exceed the limit. For example, in artemisinin-based drugs, the purity of artemisinin should reach a certain proportion, and the types and contents of other impurities should be within a controllable range to ensure the efficacy and safety of the drug.
  • Pharmacodynamics: Verify the inhibitory and killing effect of the drug on malaria parasites through in vivo and in vitro experiments to ensure that it has sufficient anti-malarial efficacy. For example, in animal models or clinical trials, observe the therapeutic effect of the drug on malaria parasite infection, including symptom relief, malaria parasite clearance time and other indicators, and it should reach the corresponding therapeutic standard.
  • Pharmacokinetics: Study the absorption, distribution, metabolism and excretion laws of the drug in the body to determine a reasonable dosage and dosage interval. For example, understand the concentration change curve of the anti-malarial drug in the blood and its distribution in different tissue organs to provide a scientific basis for clinical medication and ensure that the drug can reach an effective therapeutic concentration in the body and maintain for a certain period of time.
  • Safety: Evaluate the toxicity, side effects and adverse reactions of the drug under normal dosage to ensure the safety of patients taking the drug. Including acute toxicity tests, long-term toxicity tests, special toxicity tests, etc., as well as the study of drug interactions to avoid serious adverse reactions when the drug is combined with other commonly used drugs.
• Drug delivery devices:
  • Accuracy: Such as syringes, infusion sets and other drug delivery devices, their scales should be accurate and can precisely control the dosage of the drug to ensure that patients receive the accurate dosage of the drug.
  • Material and safety: Use materials that meet the medicinal standards, which are non-toxic, harmless and non-irritating, and will not react chemically with the drug to ensure the stability of the drug and the safety of the patient taking the drug.
  • Convenience of use: The design is reasonable, easy to operate, and can be easily used by medical staff or patients correctly to reduce the dosing error or other risks caused by improper operation.

For protective products

• Mosquito nets:
  • Material and quality: Choose materials with good breathability, durability and anti-mosquito performance to make mosquito nets. For example, the mesh density of the mosquito net should meet the standard, which can effectively block mosquitoes from entering, while ensuring air circulation, and the material of the mosquito net should have a certain strength and is not easy to be damaged.
  • Size and specification: According to different usage scenarios and needs, the mosquito net should have an appropriate size and specification, which can completely cover the sleep area and provide effective protection for the user.
  • Safety: The material of the mosquito net should meet environmental protection and safety standards, without odor and release of harmful substances, and be harmless to human health.
• Mosquito repellent:
  • Effective ingredient content: The content of the effective mosquito repellent ingredient in the mosquito repellent should meet the product label and relevant standard requirements to ensure its mosquito repellent effect. For example, the common content of DEET should be within the specified concentration range. If it is too low, the mosquito repellent effect will not be good, and if it is too high, it may have adverse effects on the human body.
  • Mosquito repellent effect: Verify the repelling effect and effective time of the mosquito repellent through laboratory tests and actual use evaluations. For example, within a certain period of time, it can make mosquitoes stay away from the area where the mosquito repellent is applied or sprayed, reducing the chance of being bitten by mosquitoes.
  • Safety: Evaluate the safety indicators of the mosquito repellent on the human skin and respiratory tract, such as irritation and toxicity. Ensure that under normal use conditions, it will not cause adverse reactions such as skin allergies, redness, and itching, and has no obvious harm to the human respiratory system, nervous system, etc.