Cell-Free DNA Blood Collection Tube

Cell-free DNA blood collection tubes have a wide range of applications in the medical and scientific research fields, as follows:

Clinical Diagnosis

• Early Tumor Screening: Tumor cells release cell-free DNA containing characteristics such as tumor-related gene mutations or methylation into the bloodstream. By collecting blood using a cell-free DNA blood collection tube and detecting the tumor-related cell-free DNA within it, it helps to detect the lesion when the tumor is still small and asymptomatic, enabling early intervention. For example, detecting the EGFR gene mutation in the blood of lung cancer patients provides a basis for early diagnosis.
• Tumor Treatment Monitoring: During the tumor treatment process, regularly collecting the patient’s blood with a cell-free DNA blood collection tube and monitoring the changes of tumor-related markers in the cell-free DNA can evaluate the treatment effect and detect the recurrence or metastasis of the tumor in a timely manner. For instance, after surgery for colorectal cancer patients, by monitoring the changes of specific cell-free DNA in the blood, it can be determined whether there are residual cancer cells or signs of recurrence.
• Prenatal Diagnosis: Pregnant women’s peripheral blood contains cell-free DNA from the fetus. Using a cell-free DNA blood collection tube to collect the pregnant woman’s blood enables non-invasive prenatal testing (NIPT) to detect whether the fetus has chromosomal numerical abnormalities, such as Down syndrome, Edwards syndrome, etc. Compared with traditional invasive detection methods like amniocentesis, it has the advantages of low risk and high accuracy.
• Transplant Rejection Monitoring: After organ transplantation, donor-derived cell-free DNA will appear in the recipient’s blood. Using a cell-free DNA blood collection tube to collect the recipient’s blood and monitoring the content and changes of the donor cell-free DNA can promptly detect the rejection reaction of the transplanted organ, allowing doctors to adjust the immunosuppressive treatment plan in a timely manner.

Disease Research

• Cardiovascular Disease Research: During the occurrence and development of cardiovascular diseases, the level and composition of cell-free DNA in the blood may change. By collecting the patient’s blood with a cell-free DNA blood collection tube and studying the relationship between cell-free DNA and cardiovascular diseases, it helps to reveal the pathogenesis of the diseases, and discover new diagnostic markers and therapeutic targets. For example, studies have found that there are specific cell-free DNA fragments in the blood of patients with acute myocardial infarction, which may be related to myocardial cell damage and repair.
• Neurological Disease Research: In the research of neurological diseases such as Alzheimer’s disease and Parkinson’s disease, cell-free DNA blood collection tubes can be used to collect the patient’s blood and analyze whether there are gene abnormalities or epigenetic changes related to the diseases in the cell-free DNA, providing clues for the early diagnosis and research on the pathogenesis of neurological diseases.
• Infectious Disease Research: In the blood of patients with infectious diseases, there may be cell-free DNA of pathogens. Using a cell-free DNA blood collection tube to collect the blood and detect the cell-free DNA of pathogens helps to quickly diagnose the infectious pathogens and monitor the treatment effect and disease progression. For example, the cell-free DNA of the novel coronavirus can be detected in the blood of COVID-19 patients, providing a reference for disease diagnosis and treatment.

Drug Development

• Drug Efficacy Evaluation: In clinical trials of drug development, using a cell-free DNA blood collection tube to collect the patient’s blood, and by detecting the changes of cell-free DNA related to the drug’s target in the blood, it can evaluate whether the drug has an effect on the target and the degree of the effect, providing an objective basis for drug efficacy evaluation.
• Adverse Drug Reaction Monitoring: Some drugs may cause cell damage or genetic changes, which in turn lead to changes in cell-free DNA in the blood. Using a cell-free DNA blood collection tube to collect the blood and monitoring the changes of cell-free DNA helps to detect adverse drug reactions at an early stage, adjust the drug dosage in a timely manner or change the drug, and ensure the safety of patients’ medication.