The following are the types of samples that can be collected using the iClean® Saliva Collection Card:

Disease – related Proteins
- Many diseases can cause changes in the levels of certain proteins in human saliva. For example, there may be specific tumor – related proteins in the saliva of patients with cancers such as oral cancer and pancreatic cancer. Using the iClean® Saliva Collection Card, saliva samples can be collected, and then laboratory tests can be performed to analyze the presence and levels of these proteins, aiding in the early diagnosis of diseases.
- For some autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus, autoantibody proteins in the saliva of patients may also be detected from the samples collected by this collection card, helping doctors evaluate the condition of the disease.
Hormones
- Saliva contains a variety of hormones. For example, cortisol, a stress hormone, saliva samples collected by the iClean® Saliva Collection Card can be used to monitor the level of human stress response. It is of great significance in psychological stress research and the diagnosis of endocrine – related diseases.
- Female sex hormones, such as estrogen and progesterone, are reflected to varying degrees in saliva under certain physiological and pathological conditions. Using the collection card to collect saliva for detecting these hormones is helpful for understanding women’s reproductive health status, such as evaluating whether the menstrual cycle is normal and monitoring hormonal changes during pregnancy.

Viruses
- For some viruses transmitted through saliva, such as Herpes Simplex Virus (HSV) and Epstein – Barr Virus (EBV), the iClean® Saliva Collection Card can conveniently collect saliva samples containing viruses. These samples can be used for laboratory tests to determine virus infection, thereby providing a basis for disease diagnosis and treatment.
- During an infectious disease outbreak, such as a flu pandemic, collecting saliva samples from a large number of people can help public health agencies quickly understand the spread range and epidemic trend of the virus, and this collection card can make the sample – collecting work more efficient and convenient.
Bacteria
- There are a large number of bacteria in the oral cavity, and some bacteria are closely related to oral diseases. For example, Streptococcus mutans, which causes dental caries, and Porphyromonas gingivalis, which causes periodontitis. Using the iClean® Saliva Collection Card to collect saliva enables the detection of these bacteria, aiding in the diagnosis and prevention of oral diseases.
- In addition, pathogenic bacteria of some systemic infectious diseases may also be present in saliva. For example, Mycobacterium tuberculosis may appear in saliva in a few cases, and this collection card can be used to collect samples for relevant tests.

DNA
- Human saliva contains oral epithelial cells, and these cells contain DNA. The iClean® Saliva Collection Card can collect DNA samples sufficient for genetic tests. In the field of forensic medicine, by collecting saliva samples left at the crime scene, DNA can be extracted for identification.
- In genetic research and clinical diagnosis, such as genetic screening for hereditary diseases, using this collection card to collect saliva to obtain DNA samples can be used to detect gene mutations, helping to determine the genetic causes of diseases.
RNA
- After some viruses infect humans, their RNA will be present in saliva. For example, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS – CoV – 2). The iClean® Saliva Collection Card can be used to collect saliva samples containing viral RNA for virus detection and research, which is of great value for epidemic prevention and control and research on disease mechanisms.
- In some research on disease mechanisms, RNA produced by human cells themselves may also be reflected in saliva, and saliva samples can be collected by the collection card for relevant research.