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The storage time of samples collected in cell – free DNA (cfDNA) blood collection tubes is influenced by multiple factors, including the type of blood collection tube, storage conditions, and the purpose of the test.

Cell - Free DNA Blood Collection Tube Class Product news Cell-Free DNA Blood Collection Tube10
  1. Type of Blood Collection Tube and Composition of Preservative
    Blood collection tubes for cfDNA produced by different manufacturers contain different preservative components, which significantly affect the sample storage time. Some high – quality blood collection tubes contain special nucleic acid preservatives, such as anticoagulants like ethylenediaminetetraacetic acid (EDTA) and citrate, as well as components that can inhibit the activity of nucleases. These preservatives can prevent cfDNA from being degraded by nucleases in the blood. Under ideal conditions, such blood collection tubes can preserve the cfDNA in the sample for several months or even years. For example, some specially designed blood collection tubes can ensure that the cfDNA in blood samples remains suitable for subsequent genetic testing after being stored at 2 – 8 °C for 3 – 5 years.
  2. Storage Conditions
    • Temperature
      Temperature is one of the key factors affecting the sample storage time. Generally, lower temperatures are conducive to prolonging the storage time of samples. If the samples are stored in a low – temperature environment of – 20 °C or – 80 °C, the cfDNA in the samples can be preserved for a longer time. In an ultra – low – temperature environment, molecular motion slows down, and the activity of nucleases is also greatly inhibited, reducing the degradation of cfDNA. For example, in research projects, samples collected using cfDNA blood collection tubes are stored in an ultra – low – temperature freezer at – 80 °C. After many years, the cfDNA in the samples can still maintain good integrity and can be used for retrospective studies or to verify previous test results. However, even in a low – temperature environment, care should be taken to avoid repeated freeze – thaw cycles, as this may lead to the fragmentation and degradation of cfDNA.
    • Light and Humidity
      In addition to temperature, light and humidity can also have a certain impact on sample storage. Prolonged exposure to strong light may cause photochemical reactions of some components in the sample, affecting the stability of cfDNA. A high – humidity environment may cause damage to the labels of blood collection tubes, sample contamination, or the failure of the preservative. Therefore, samples usually need to be stored in a light – proof and dry environment to extend the storage time.
  3. Requirements of the Testing Purpose for Storage Time
    Different testing purposes have different requirements for the sample storage time. For some tests with extremely high requirements for cfDNA integrity, such as gene sequencing, the test may need to be carried out within a short period, generally recommended within a few days to a few weeks after collection, to ensure the most accurate genetic information can be obtained. This is because over time, even under good storage conditions, cfDNA may undergo a certain degree of degradation or minor changes, affecting the accuracy of the sequencing results. However, for some situations where only the presence or absence of cfDNA needs to be detected or simple quantitative analysis (such as viral load detection) is required, the sample may still meet the testing requirements after being stored for several months. For example, in the monitoring of some chronic viral infections, blood samples collected using cfDNA blood collection tubes can still be used to detect the approximate content of viral cfDNA through appropriate testing methods after being stored for several months, which is used to assess the viral infection status.
Cell-Free DNA Blood Collection Tube
Cell-Free DNA Blood Collection Tube
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