Sample Preservation Solution: A Key Element to Ensure Sample Quality”

Sample preservation solution shows irreplaceable value in many fields.

I. Specific Applications

In the field of gene testing, sample preservation solution is essential. Whether it is prenatal gene testing or genetic disease diagnosis, samples such as blood, amniotic fluid, or villi of patients need to be collected. The sample preservation solution can ensure the integrity of DNA or RNA in these samples. For example, in non – invasive prenatal gene testing, after the peripheral blood sample of a pregnant woman is placed in the preservation solution, the free fetal DNA in it can be ensured not to be degraded during transportation and short – term storage, providing a guarantee for accurately detecting whether the fetus has chromosomal abnormality diseases later.

In forensic identification, sample preservation solution also has important applications. Biological samples such as blood, hair, and semen collected at crime scenes can be preserved for a long time after being placed in the preservation solution, facilitating subsequent DNA analysis and providing strong evidence support for case – solving.

In the biopharmaceutical industry, for cell samples collected during the research and development process, sample preservation solution can maintain the activity and function of cells. For example, in the research and development of monoclonal antibodies, the preservation of hybridoma cells needs to rely on appropriate sample preservation solution, so as to ensure the production of high – quality and active monoclonal antibodies later.

II. Usage Methods

When collecting cell samples for preservation, first digest the cells from the culture dish with reagents such as trypsin, and then slowly transfer the cell suspension to a centrifuge tube containing sample preservation solution. The centrifuge tube should be marked in advance, indicating the source of the sample, collection time, and other information.

For blood samples, if it is whole – blood preservation, add blood and preservation solution according to the proportion specified in the instruction manual of the preservation solution. If it is preservation after extracting plasma or serum, put it into the preservation solution as soon as possible after the separation operation.

III. Characteristics

Sample preservation solution has a high degree of stability. It can maintain its sample – preserving performance at different environmental temperatures (within its specified storage temperature range). Moreover, its formulation is targeted and can be optimized for specific types of samples. For example, the preservation solution specifically used for preserving virus samples will consider factors such as the envelope structure and living environment of the virus to design the formulation.

Sample preservation solution also has a certain degree of universality and can be compatible with multiple similar samples within a certain range. For example, some preservation solutions suitable for various human tissue samples can reduce the cost and operational complexity of sample preservation in the laboratory.

IV. Precautions

During the use of sample preservation solution, pay attention to avoiding cross – contamination. Containers of preservation solutions for different samples cannot be mixed. If multiple samples are processed in the same work area, clean and disinfect the tools after each operation.

Strictly follow the storage time specified in the instruction manual of the sample preservation solution to preserve the sample. Exceeding the storage time may lead to a decline in sample quality and affect testing or research results.

When transporting containers containing sample preservation solution and samples, appropriate packaging and protective measures should be taken to prevent container breakage and sample leakage, ensuring biosafety during transportation.