TOC Cleaning Validation Swab

Total Organic Carbon Cleaning Validation Swab is a tool used to detect the residual organic carbon on the surface of an object. The following is its specific introduction:

Specific applications

• Pharmaceutical industry: In the process of drug production, the cleanliness of equipment is directly related to the quality and safety of drugs. The total organic carbon cleaning validation swab can be used to detect the residual organic carbon on the surface of pharmaceutical equipment to ensure that the equipment has been thoroughly cleaned before producing different batches of drugs, preventing cross-contamination and ensuring the quality and stability of the drugs and compliance with standards.
• Food processing industry: The cleaning of food production equipment needs to be regularly verified to avoid organic pollutants from contaminating food. This swab can be used to detect the residual organic carbon on the surface of food processing equipment, containers, etc., to ensure the hygienic safety of the food production environment, prevent food from being contaminated by harmful substances, and protect the health of consumers.
• Microelectronics industry: Even tiny organic pollutants can affect the performance and quality of electronic products in the microelectronics manufacturing process. The total organic carbon cleaning validation swab can detect the residual organic carbon on the surface of chip manufacturing equipment, circuit boards, etc., to ensure the cleanliness of the microelectronics production process and improve the yield of products.
• Medical device industry: The cleaning of medical devices is crucial for the safety of patients. Using the total organic carbon cleaning validation swab can detect the residual organic carbon on the surface of medical devices to ensure that the device has reached the required cleaning standard before use, reducing the risk of infection.

Characteristics

• Low background value of organic carbon: After special treatment, it has an extremely low background value of organic carbon, usually less than 50 µg/l or 50 ppb, which can ensure the accuracy of the detection result and avoid the interference of the organic carbon of the swab itself to the sample detection.
• Efficient pollutant interception ability: Using double-layer, double-sided knitted polyester head and other materials, it can effectively intercept pollutants during the wiping process and fully release them into the diluent in the subsequent extraction process, ensuring a high recovery rate, thereby more accurately reflecting the organic carbon pollution situation on the detected surface.
• Material is safe and without interference: The head and handle of the swab are usually made of polyester fiber, polypropylene and other materials, which do not contain organic pollutants, silicon, ammonia, phthalate esters and other substances, and will not interfere with the detection results. At the same time, it has good chemical resistance and can be applied to various solvents and chemical environments.
• Convenient operation and processing: It has an easy-to-break handle design. After sampling, the head can be easily broken and placed in the sample receiving test tube or vial, the operation is simple, reducing the risk of pollution during processing and improving work efficiency.
• Traceability and quality control: Each batch of swabs has a corresponding batch number code, which is convenient for traceability and quality control to ensure the quality and performance stability and reliability of the product.

Usage method

• Preparation work: Before use, it is necessary to ensure that the equipment or surface to be detected has stopped running and is in a clean state. At the same time, check whether the packaging of the swab is intact, confirm the size of the swab used is suitable for the surface to be detected, and prepare the corresponding sample receiving container, extraction solvent, etc.
• Wiping and sampling: Gently open the packaging of the swab, and avoid touching the head of the swab with your hands. Bring the head of the swab close to the surface to be detected, making the angle between the swab head and the surface 45°, and wipe the surface to be sampled back and forth with gentle and smooth slow movements to ensure that the entire surface is wiped. Generally, the wiping area of each swab is 25 cm². When wiping, attention should be paid to avoid excessive force to prevent scratches or damage to the surface. After wiping, the swab can be reversed to let the other side wipe as well, but the moving direction of this wiping should be perpendicular to the previous one to collect pollutants more comprehensively.
• Sample processing: After wiping is completed, separate the head of the swab at the breakpoint and put it into a vial containing an acidic solution or other suitable extraction solvent. Then, you can choose to perform ultrasonic or centrifugal processing to fully release the organic carbon into the solvent for subsequent analysis of the total organic carbon concentration. You can also follow a specific analytical method, such as putting the swab into a sealed glass ampoule containing 5% phosphoric acid and 100 g/l sodium persulfate solution, analyzing the swab immersion liquid, purging the inorganic carbon in the form of carbon dioxide to the environment, heating the glass bottle to 100 °C and keeping it for a specified time, and finally opening the glass bottle to blow out the toc in the form of carbon dioxide for detection.