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The application scenarios of cell – free DNA blood collection tubes mainly include the following aspects:

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  1. Prenatal Diagnosis
    • Non – Invasive Prenatal Testing (NIPT)
      • This is an important application area of cell – free DNA blood collection tubes. There is a small amount of fetal cell – free DNA in the peripheral blood of pregnant women. By collecting the blood of pregnant women and using cell – free DNA blood collection tubes for preservation and transportation, the fetal cell – free DNA can be detected and analyzed to determine whether there are chromosomal abnormalities in the fetus, such as Down syndrome, Edwards syndrome, and Patau syndrome. This method has the advantages of being non – invasive, highly safe, and having relatively high accuracy, avoiding the risks such as miscarriage associated with traditional invasive prenatal diagnosis methods like amniocentesis.
  2. Tumor Diagnosis and Monitoring
    • Early Tumor Screening
      • In the early stage of tumor occurrence, tumor cells release DNA fragments into the blood, forming circulating tumor DNA (ctDNA). By using cell – free DNA blood collection tubes to collect patients’ blood and detecting the ctDNA in it, early tumor screening can be achieved, which helps to discover diseases before the tumors develop obvious symptoms and provides opportunities for early treatment.
    • Tumor Treatment Monitoring
      • During the treatment process of tumor patients, regularly collecting blood and using cell – free DNA blood collection tubes for preservation and detecting changes in ctDNA can evaluate the treatment effect, such as determining whether the tumor responds to treatment and whether there is drug resistance, providing a basis for doctors to adjust treatment plans in a timely manner.
    • Tumor Prognosis Evaluation
      • By detecting the level of ctDNA in the blood of patients after treatment, the risk of tumor recurrence and the prognosis of patients can be predicted, helping doctors to formulate follow – up and treatment plans.
  3. Organ Transplantation
    • Transplant Rejection Monitoring
      • After organ transplantation, the recipient’s immune system may have a rejection reaction to the transplanted organ. By using cell – free DNA blood collection tubes to collect the recipient’s blood and detecting the level of donor – derived cell – free DNA in it, signs of transplant rejection can be detected early, providing a basis for timely anti – rejection treatment and improving the survival rate of transplanted organs and the quality of life of patients.
    • Transplant Organ Injury Assessment
      • In addition to rejection reactions, transplanted organs may also be damaged by other factors, such as ischemia – reperfusion injury. Detecting the level of cell – free DNA in the blood can assist in assessing the degree of injury to transplanted organs and help doctors understand the functional status of transplanted organs.
  4. Cardiovascular Disease Diagnosis
    • The occurrence and development of cardiovascular diseases are related to factors such as gene mutations. After using cell – free DNA blood collection tubes to collect patients’ blood and analyzing the relevant gene fragments in it, gene mutations, methylation and other abnormalities related to cardiovascular diseases can be found, providing references for the diagnosis, risk assessment, and treatment of cardiovascular diseases. For example, detecting the methylation level of certain specific genes can predict the risk of coronary heart disease.
  5. Infectious Disease Diagnosis
    • In infectious diseases, after pathogens infect the human body, they will cause the host’s immune response, resulting in changes in the level and composition of cell – free DNA in the blood. By using cell – free DNA blood collection tubes to collect patients’ blood and analyzing the characteristics of cell – free DNA in it, infectious diseases such as bacterial infections and viral infections can be diagnosed, and the severity of infections and treatment effects can be monitored.
  6. Medical Research
    • In medical research, cell – free DNA blood collection tubes provide researchers with a convenient and reliable way to collect and preserve blood samples, which is helpful for carrying out various studies related to cell – free DNA. For example, studying the change rules of cell – free DNA under different disease states, exploring new disease markers, validating new detection methods and technologies, etc., providing new ideas and methods for disease diagnosis and treatment.
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